At first, I thought the yarn would be a tangled mess, I would lose track of the needle(s) or some other random excuse. The truth is that it's pretty simple to figure this all out. Maybe a tiny bit more fiddling and sorting the yarn is in order if you're using multiple skeins but it isn't so bad.
Some of my more inspiring insta-friends have been whipping socks out and there I was, afraid to let go...